abstract：:Phosphoglycerate dehydrogenase (PHGDH) is the metabolic enzyme responsible for shunting the glycolytic intermediate 3-phosphoglycerate to the serine synthesis pathway. In breast cancer and several other types of cancer, increased PHGDH expression is associated with patient mortality. Early studies focused on the role ...

journal_title：Cancer research

authors： Samanta D,Semenza GL

更新日期：2016-11-15 00:00:00

abstract：:Squamous cell carcinoma (SCC) and keratoacanthoma (KA; SCC/KA) research has been hampered mainly by our lack of understanding the underlying genetic and epigenetic alterations associated with SCC/KA development, as well as the lack of animal models that faithfully recapitulate histopathologic features of human SCC/KA....

journal_title：Cancer research

authors： Lee JH,Lee JH,Lee SH,Do SI,Cho SD,Forslund O,Inn KS,Lee JS,Deng FM,Melamed J,Jung JU,Jeong JH

更新日期：2016-11-15 00:00:00

abstract：:Cancer research has long been hampered by the limitations of the current model systems. Both cultured cells and mouse xenografts grow in an environment highly dissimilar to that of their originating tumor, frequently resulting in promising treatments that are ultimately clinically ineffective. The development of highl...

journal_title：Cancer research

authors： Morton JJ,Bird G,Refaeli Y,Jimeno A

更新日期：2016-11-01 00:00:00

abstract：:SMYD3 methyltransferase is nearly undetectable in normal human tissues but highly expressed in several cancers, including breast cancer, although its contributions to pathogenesis in this setting are unclear. Here we report that histone H2A.Z.1 is a substrate of SMYD3 that supports malignancy. SMYD3-mediated dimethyla...

journal_title：Cancer research

authors： Tsai CH,Chen YJ,Yu CJ,Tzeng SR,Wu IC,Kuo WH,Lin MC,Chan NL,Wu KJ,Teng SC

更新日期：2016-10-15 00:00:00

abstract：:A sound rationale exists for antibody targeting of the MET receptor tyrosine kinase, but therapeutic agents that can broadly block HGF ligand binding and exon 14-mutated or amplified MET to induce receptor degradation have yet to be reported. Here we report the identification of several MET monoclonal antibodies (mAb)...

journal_title：Cancer research

authors： Yang Y,Mandiyan S,Robinson BS,McMahon G

更新日期：2016-10-01 00:00:00

abstract：:Histopathological assessment of lymph node metastases (LNM) depends on subjective analysis of cellular morphology with inter-/intraobserver variability. In this study, LNM from esophageal adenocarcinoma was objectively detected using desorption electrospray ionization-mass spectrometry imaging (DESI-MSI). Ninety lymph...

journal_title：Cancer research

authors： Abbassi-Ghadi N,Golf O,Kumar S,Antonowicz S,McKenzie JS,Huang J,Strittmatter N,Kudo H,Jones EA,Veselkov K,Goldin R,Takats Z,Hanna GB

更新日期：2016-10-01 00:00:00

abstract：:Hypoxia is a common feature of solid tumors, which controls multiple aspects of cancer progression. One important function of hypoxia and the hypoxia-inducible factors (HIF) is the maintenance of cancer stem-like cells (CSC), a population of tumor cells that possess stem cell-like properties and drives tumor growth. A...

journal_title：Cancer research

authors： Filatova A,Seidel S,Böğürcü N,Gräf S,Garvalov BK,Acker T

更新日期：2016-10-01 00:00:00

abstract：:Chromatin modification is pivotal to the epithelial-mesenchymal transition (EMT), which confers potent metastatic potential to cancer cells. Here, we report a role for the chromatin remodeling factor lymphoid-specific helicase (LSH) in nasopharyngeal carcinoma (NPC), a prevalent cancer in China. LSH expression was inc...

journal_title：Cancer research

authors： He X,Yan B,Liu S,Jia J,Lai W,Xin X,Tang CE,Luo D,Tan T,Jiang Y,Shi Y,Liu Y,Xiao D,Chen L,Liu S,Mao C,Yin G,Cheng Y,Fan J,Cao Y,Muegge K,Tao Y

更新日期：2016-10-01 00:00:00

abstract：:Estrogen receptor α (ERα) is a key regulator of breast growth and breast cancer development. Here, we report how ERα impacts these processes by reprogramming metabolism in malignant breast cells. We employed an integrated approach, combining genome-wide mapping of chromatin-bound ERα with estrogen-induced transcript a...

journal_title：Cancer research

authors： Jia M,Andreassen T,Jensen L,Bathen TF,Sinha I,Gao H,Zhao C,Haldosen LA,Cao Y,Girnita L,Moestue SA,Dahlman-Wright K

更新日期：2016-10-01 00:00:00

abstract：:Metastatic prostate cancer continues to pose a difficult therapeutic challenge. Prostate cancer progression is associated with aberrant O-glycosylation of cancer cell surface receptors, but the functional impact of such events is uncertain. Here we report spontaneous metastasis of human prostate cancer xenografts that...

journal_title：Cancer research

authors： Tsai CH,Tzeng SF,Chao TK,Tsai CY,Yang YC,Lee MT,Hwang JJ,Chou YC,Tsai MH,Cha TL,Hsiao PW

更新日期：2016-10-01 00:00:00

abstract：:p21 (WAF1/CIP1; CDKN1a) is a universal cell-cycle inhibitor directly controlled by p53 and p53-independent pathways. Knowledge of the regulation and function of p21 in normal and cancer cells has opened up several areas of investigation and has led to novel therapeutic strategies. The discovery in 1993 and subsequent ...

journal_title：Cancer research

authors： El-Deiry WS

更新日期：2016-09-15 00:00:00

abstract：:The degree of heterogeneity among cancer stem cells (CSC) remains ill-defined and may hinder effective anti-CSC therapy. Evaluation of oral cancers for such heterogeneity identified two compartments within the CSC pool. One compartment was detected using a reporter for expression of the H3K4me3 demethylase JARID1B to ...

journal_title：Cancer research

authors： Facompre ND,Harmeyer KM,Sole X,Kabraji S,Belden Z,Sahu V,Whelan K,Tanaka K,Weinstein GS,Montone KT,Roesch A,Gimotty PA,Herlyn M,Rustgi AK,Nakagawa H,Ramaswamy S,Basu D

更新日期：2016-09-15 00:00:00

abstract：:Organization of cancer cells into endothelial-like cell-lined structures to support neovascularization and to fuel solid tumors is a hallmark of progression and poor outcome. In triple-negative breast cancer (TNBC), PDGFRβ has been identified as a key player of this process and is considered a promising target for bre...

journal_title：Cancer research

authors： D'Ippolito E,Plantamura I,Bongiovanni L,Casalini P,Baroni S,Piovan C,Orlandi R,Gualeni AV,Gloghini A,Rossini A,Cresta S,Tessari A,De Braud F,Di Leva G,Tripodo C,Iorio MV

更新日期：2016-09-15 00:00:00

abstract：:KANSL2 is an integral subunit of the nonspecific lethal (NSL) chromatin-modifying complex that contributes to epigenetic programs in embryonic stem cells. In this study, we report a role for KANSL2 in regulation of stemness in glioblastoma (GBM), which is characterized by heterogeneous tumor stem-like cells associated...

journal_title：Cancer research

authors： Ferreyra Solari NE,Belforte FS,Canedo L,Videla-Richardson GA,Espinosa JM,Rossi M,Serna E,Riudavets MA,Martinetto H,Sevlever G,Perez-Castro C

更新日期：2016-09-15 00:00:00

abstract：:Cachexia is a life-threatening wasting syndrome lacking effective treatment, which arises in many cancer patients. Although ostensibly induced by multiple tumor-produced cytokines (tumorkines), their functional contribution to initiation and progression of this syndrome has proven difficult to determine. In this study...

journal_title：Cancer research

authors： Chen JL,Walton KL,Qian H,Colgan TD,Hagg A,Watt MJ,Harrison CA,Gregorevic P

更新日期：2016-09-15 00:00:00

abstract：:The intermediate filament protein Nestin serves as a biomarker for stem cells and has been used to identify subsets of cancer stem-like cells. However, the mechanistic contributions of Nestin to cancer pathogenesis are not understood. Here, we report that Nestin binds the hedgehog pathway transcription factor Gli3 to ...

journal_title：Cancer research

authors： Li P,Lee EH,Du F,Gordon RE,Yuelling LW,Liu Y,Ng JM,Zhang H,Wu J,Korshunov A,Pfister SM,Curran T,Yang ZJ

更新日期：2016-09-15 00:00:00

abstract：:The relatively recent clinical success of bortezomib, particularly in multiple myeloma, has established the validity of the proteasome as a viable target for anticancer drug development. This highly cited 1999 Cancer Research article from Adams and colleagues was published during the period when this drug was transiti...

journal_title：Cancer research

authors： Tew KD

更新日期：2016-09-01 00:00:00

abstract：:In principle, the inhibition of candidate gain-of-function genes defined through genomic analyses of large patient cohorts offers an attractive therapeutic strategy. In this study, we focused on changes in expression of CD24, a well-validated clinical biomarker of poor prognosis and a driver of tumor growth and metast...

journal_title：Cancer research

authors： Agarwal N,Dancik GM,Goodspeed A,Costello JC,Owens C,Duex JE,Theodorescu D

更新日期：2016-09-01 00:00:00

abstract：:The ability to engineer specific mutations in mice has proven essential to advancing our understanding of the molecular basis of cancer. Chromosomal rearrangements, a common and clinically relevant class of cancer-causing mutations, have however remained difficult to faithfully recapitulate in vivo The development of ...

journal_title：Cancer research

authors： Maddalo D,Ventura A

更新日期：2016-09-01 00:00:00

abstract：:The receptor Notch1 plays an important role in malignant progression of many cancers, but its regulation is not fully understood. In this study, we report that the kinase HIPK2 is responsible for facilitating the Fbw7-dependent proteasomal degradation of Notch1 by phosphorylating its intracellular domain (Notch1-IC) w...

journal_title：Cancer research

authors： Ann EJ,Kim MY,Yoon JH,Ahn JS,Jo EH,Lee HJ,Lee HW,Kang HG,Choi DW,Chun KH,Lee JS,Choi CY,Ferrando AA,Lee K,Park HS

更新日期：2016-08-15 00:00:00

abstract：:The aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2) splice variant designated DX2 is induced by cigarette smoke carcinogens and is often detected in human lung cancer specimens. However, the function of DX2 in lung carcinogenesis is obscure. In this study, we found that DX2 expression w...

journal_title：Cancer research

authors： Oh AY,Jung YS,Kim J,Lee JH,Cho JH,Chun HY,Park S,Park H,Lim S,Ha NC,Park JS,Park CS,Song GY,Park BJ

更新日期：2016-08-15 00:00:00

abstract：:Other than an association with HPV infection, little is known about the genetic alterations determining the development of penile cancer. Although penile cancer is rare in the developed world, it presents a significant burden in developing countries. Here, we report the findings of whole-exome sequencing (WES) to dete...

journal_title：Cancer research

authors： Feber A,Worth DC,Chakravarthy A,de Winter P,Shah K,Arya M,Saqib M,Nigam R,Malone PR,Tan WS,Rodney S,Freeman A,Jameson C,Wilson GA,Powles T,Beck S,Fenton T,Sharp TV,Muneer A,Kelly JD

更新日期：2016-08-15 00:00:00

abstract：:Inflammation predisposes to tumorigenesis in various organs by potentiating a susceptibility to genetic aberrations. The mechanism underlying the enhanced genetic instability through chronic inflammation, however, is not clear. Here, we demonstrated that TNFα stimulation induced transcriptional downregulation of MSH2,...

journal_title：Cancer research

authors： Eso Y,Takai A,Matsumoto T,Inuzuka T,Horie T,Ono K,Uemoto S,Lee K,Edelmann W,Chiba T,Marusawa H

更新日期：2016-08-01 00:00:00

abstract：:Fibroblast growth factor receptor 3 (FGFR3) plays important roles in cell proliferation, differentiation, and angiogenesis. FGFR3 is abnormally upregulated in hepatocellular carcinoma (HCC), where it correlates positively with clinicopathologic index, HCC differentiation, and advanced nuclear grade. In this study, we ...

journal_title：Cancer research

authors： Li K,Shen B,Cheng X,Ma D,Jing X,Liu X,Yang W,Peng C,Qiu W

更新日期：2016-07-15 00:00:00

abstract：:Malignant glioma is an often fatal type of cancer. Aberrant activation of STAT3 leads to glioma tumorigenesis. STAT3-induced transcription of protein-coding genes has been extensively studied; however, little is known about STAT3-regulated miRNA gene transcription in glioma tumorigenesis. In this study, we found that ...

journal_title：Cancer research

authors： Xue J,Zhou A,Wu Y,Morris SA,Lin K,Amin S,Verhaak R,Fuller G,Xie K,Heimberger AB,Huang S

更新日期：2016-07-15 00:00:00

abstract：:A major objective of the emerging field of exercise-oncology research is to determine the efficacy of, and biological mechanisms by which, aerobic exercise affects cancer incidence, progression, and/or metastasis. There is a strong inverse association between self-reported exercise and the primary incidence of several...

journal_title：Cancer research

authors： Ashcraft KA,Peace RM,Betof AS,Dewhirst MW,Jones LW

更新日期：2016-07-15 00:00:00

abstract：:Tumor hypoxia is associated clinically with therapeutic resistance and poor patient outcomes. One feature of tumor hypoxia is activated expression of carbonic anhydrase IX (CA9), a regulator of pH and tumor growth. In this study, we investigated the hypothesis that impeding the reuptake of bicarbonate produced extrace...

journal_title：Cancer research

authors： McIntyre A,Hulikova A,Ledaki I,Snell C,Singleton D,Steers G,Seden P,Jones D,Bridges E,Wigfield S,Li JL,Russell A,Swietach P,Harris AL

更新日期：2016-07-01 00:00:00

abstract：:Pancreatic cancers with aberrant expression of macrophage migration inhibitory factor (MIF) are particularly aggressive. To identify key signaling pathways that drive disease aggressiveness in tumors with high MIF expression, we analyzed the expression of coding and noncoding genes in high and low MIF-expressing tumor...

journal_title：Cancer research

authors： Yang S,He P,Wang J,Schetter A,Tang W,Funamizu N,Yanaga K,Uwagawa T,Satoskar AR,Gaedcke J,Bernhardt M,Ghadimi BM,Gaida MM,Bergmann F,Werner J,Ried T,Hanna N,Alexander HR,Hussain SP

更新日期：2016-07-01 00:00:00

abstract：:Paclitaxel is a standard-of-care chemotherapy for breast cancer, despite the increasing recognition of its poor effectiveness in the treatment of patients with advanced disease. Here, we report that adenovirus-type 5 E1A-mediated elevation of the miRNA-processing enzyme Dicer is sufficient to enhance paclitaxel sensit...

journal_title：Cancer research

authors： Chang TY,Chen HA,Chiu CF,Chang YW,Kuo TC,Tseng PC,Wang W,Hung MC,Su JL

更新日期：2016-07-01 00:00:00

abstract：:RAF kinase inhibitor protein (RKIP) is a seminal regulator of intracellular signaling and exhibits both antimetastatic and antitumorigenic properties. Decreased expression of RKIP has been described in several human malignancies, including acute myelogenous leukemia (AML). As the mechanisms leading to RKIP loss in AML...

journal_title：Cancer research

authors： Hatzl S,Geiger O,Kuepper MK,Caraffini V,Seime T,Furlan T,Nussbaumer E,Wieser R,Pichler M,Scheideler M,Nowek K,Jongen-Lavrencic M,Quehenberger F,Wölfler A,Troppmair J,Sill H,Zebisch A

更新日期：2016-06-15 00:00:00

abstract：:Integrin β3 is critical for tumor invasion, neoangiogenesis, and inflammation, making it a promising cancer target. However, preclinical and clinical data of integrin β3 antagonists have demonstrated no benefit or worse outcomes. We hypothesized that integrin β3 could affect tumor immunity and evaluated tumors in mice...

journal_title：Cancer research

authors： Su X,Esser AK,Amend SR,Xiang J,Xu Y,Ross MH,Fox GC,Kobayashi T,Steri V,Roomp K,Fontana F,Hurchla MA,Knolhoff BL,Meyer MA,Morgan EA,Tomasson JC,Novack JS,Zou W,Faccio R,Novack DV,Robinson SD,Teitelbaum SL,DeNar

更新日期：2016-06-15 00:00:00

abstract：:Multiple myeloma cells secrete more disulfide bond-rich proteins than any other mammalian cell. Thus, inhibition of protein disulfide isomerases (PDI) required for protein folding in the endoplasmic reticulum (ER) should increase ER stress beyond repair in this incurable cancer. Here, we report the mechanistically unb...

journal_title：Cancer research

authors： Vatolin S,Phillips JG,Jha BK,Govindgari S,Hu J,Grabowski D,Parker Y,Lindner DJ,Zhong F,Distelhorst CW,Smith MR,Cotta C,Xu Y,Chilakala S,Kuang RR,Tall S,Reu FJ

更新日期：2016-06-01 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is an aggressive malignant tumor that secretes various angiogenic factors. The main inhibitor of plasminogen activators, PAI-1 (SERPINE1), has been implicated in tumor progression and angiogenesis, and high PAI-1 expression has been associated with poor prognosis in MPM patients. I...

journal_title：Cancer research

authors： Takayama Y,Hattori N,Hamada H,Masuda T,Omori K,Akita S,Iwamoto H,Fujitaka K,Kohno N

更新日期：2016-06-01 00:00:00

abstract：:Colorectal cancer cells with stem-like properties, referred to as colon cancer-initiating cells (CCIC), have high tumorigenic potential. While CCIC can differentiate to promote cellular heterogeneity, it remains unclear whether CCIC within a tumor contain distinct subpopulations. Here, we describe the co-existence of ...

journal_title：Cancer research

authors： Srinivasan T,Walters J,Bu P,Than EB,Tung KL,Chen KY,Panarelli N,Milsom J,Augenlicht L,Lipkin SM,Shen X

更新日期：2016-06-01 00:00:00

abstract：:Genome-wide association studies (GWAS) of bladder cancer have identified a number of susceptibility loci in European populations but have yet to uncover the genetic determinants underlying bladder cancer incidence among other ethnicities. Therefore, we performed the first GWAS in a Chinese cohort comprising 3,406 case...

journal_title：Cancer research

authors： Wang M,Li Z,Chu H,Lv Q,Ye D,Ding Q,Xu C,Guo J,Du M,Chen J,Song Z,Yin C,Qin C,Gu C,Zhu Y,Xia G,Liu F,Zhang Z,Yuan L,Fu G,Hu Z,Tong N,Shen J,Liu K,Sun J,Sun Y,Li J,Li X,Shen H,Xu J,Shi Y,Zhang

更新日期：2016-06-01 00:00:00

abstract：:FGF2 signaling in glioblastoma induces resistance to radiotherapy, so targeting FGF2/FGFR pathways might offer a rational strategy for tumor radiosensitization. To investigate this possibility, we evaluated a specific role for FGFR1 in glioblastoma radioresistance as modeled by U87 and LN18 glioblastomas in mouse xeno...

journal_title：Cancer research

authors： Gouazé-Andersson V,Delmas C,Taurand M,Martinez-Gala J,Evrard S,Mazoyer S,Toulas C,Cohen-Jonathan-Moyal E

更新日期：2016-05-15 00:00:00

abstract：:While showing promise, vaccination strategies to treat cancer require further optimization. Likely barriers to efficacy involve cancer-associated immunosuppression and peripheral tolerance, which limit the generation of effective vaccine-specific cytotoxic T lymphocytes (CTL). Because CD4(+) T cells improve CTL respon...

journal_title：Cancer research

authors： Ahrends T,Bąbała N,Xiao Y,Yagita H,van Eenennaam H,Borst J

更新日期：2016-05-15 00:00:00

abstract：:Glioblastoma is the most aggressive primary brain tumor and responds poorly to currently available therapies. Transcriptomic characterization of glioblastoma has identified distinct molecular subtypes of glioblastoma. Gain-of-function alterations leading to enhanced platelet-derived growth factor (PDGF) signaling are ...

journal_title：Cancer research

authors： Rahme GJ,Zhang Z,Young AL,Cheng C,Bivona EJ,Fiering SN,Hitoshi Y,Israel MA

更新日期：2016-05-15 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is considered an early onset subtype of breast cancer that carries with it a poorer prognosis in young rather than older women for reasons that remain poorly understood. Hematopoiesis in the bone marrow becomes altered with age and may therefore affect the composition of tumor-infi...

journal_title：Cancer research

authors： Marsh T,Wong I,Sceneay J,Barakat A,Qin Y,Sjödin A,Alspach E,Nilsson B,Stewart SA,McAllister SS

更新日期：2016-05-15 00:00:00

abstract：:The effects of vascular endothelial growth factor-A (VEGF-A/VEGF) and its receptors on endothelial cells function have been studied extensively, but their effects on tumor cells are less well defined. Studies of human colorectal cancer cells where the VEGF gene has been deleted suggest an intracellular role of VEGF as...

journal_title：Cancer research

authors： Bhattacharya R,Ye XC,Wang R,Ling X,McManus M,Fan F,Boulbes D,Ellis LM

更新日期：2016-05-15 00:00:00